Can You Do TMS While Taking Antidepressants?

Medically reviewed by: Dr. David Roth, MD, DFAACAP, FAPA, FAAP

September 30, 2026

"Short answer: yes. Taking antidepressants doesn’t disqualify you from TMS, and for many patients, the two are used together as part of the same treatment plan. Here’s what that actually looks like, and when a different approach might be recommended instead."

Dr. Roth explaining how TMS Works

One of the most common questions before starting TMS is whether it means stopping current medication first. It doesn’t, and understanding why helps explain how TMS actually fits into a broader treatment plan rather than replacing one entirely.


Why the two aren’t mutually exclusive

TMS and antidepressants work through different mechanisms. Antidepressants adjust neurotransmitter activity systemically, throughout the brain and body. TMS delivers targeted magnetic stimulation to specific brain circuits involved in mood regulation, without circulating through the bloodstream. Because they act on different systems, using both together is a normal part of care, not a conflict to manage.


What the clinicians at Bluegrass Advanced Mental Health evaluate before recommending combined treatment

During your evaluation, the clinicians at Bluegrass Advanced Mental health review:

  • Your current medication, dosage, and how long you’ve been on it
  • Your response so far, partial improvement, no improvement, or side effects that haven’t resolved
  • Whether your symptoms suggest TMS alone, TMS alongside your current medication, or a medication adjustment first
  • This isn’t a one-size-fits-all decision. Some patients continue their exact current regimen throughout TMS treatment; others make small adjustments alongside starting TMS, based on provider's clinical judgment.


When a taper might be recommended instead

In some cases, particularly when a current medication isn’t providing benefit and has significant side effects, the clinicians at Bluegrass Advanced Mental Health may recommend adjusting or tapering it as part of your overall plan. This is a case-by-case clinical decision, not a default requirement of starting TMS.


Key takeaways

  • Taking antidepressants does not disqualify you from TMS at Bluegrass
  • TMS and antidepressants work through different mechanisms, which is why combining them is common
  • The clinicians at BAMH evaluate your specific medication history and response before recommending whether to continue, adjust, or combine treatments
  • Any medication changes are a clinical decision made with your provider, not a requirement to start TMS


Frequently asked questions

  • Do I need to stop my antidepressant before starting TMS? No. Most patients continue their current medication throughout TMS treatment. Any changes are made based on your individual evaluation with your provider.
  • Will combining TMS and medication make either one less effective? There’s no indication that combining the two reduces effectiveness. Many patients use both as part of the same treatment plan specifically because they work through different mechanisms.
  • What if my antidepressant isn’t helping at all? That’s actually one of the most common reasons patients seek out TMS in the first place. The clinicians at Bluegrass Advanced Mental Health will discuss whether to continue, adjust, or taper your current medication as part of your overall plan.


Wondering how TMS would fit alongside your current treatment? See if you qualify. The providers at Bluegrass Advanced Mental Health will walk through your specific situation.


Recent Posts

Dr Roth mapping an adolescent for BrainsWay TMS
By David Roth • September 29, 2026
Learn about TMS therapy costs, insurance coverage, and financing options at Bluegrass Advanced Mental Health. Get expert help today!
Nurse Kim Woods explaining how TMS works to older patient
By David Roth • September 14, 2026
How TMS works, what a session feels like, and Standard vs. Accelerated options, medically reviewed by Dr. David Roth. Louisville, KY.